Ocular
Lubricants

Dry Eye
Syndrome

Dry Eye Syndrome

The new definition of dry eye as well as a new classification system are contained in the Film & Ocular Surface Society (TFOS) Dry Eye Workshop II (DEWS II) report which was published on July 21, 2017. It has impacted the way the disease is diagnosed and examined.

TREHAPAN^®

Re-establish the optimal balance of your eyes with TREHAPAN®.

Thanks to the unique combination of three active substances: trehalose, sodium hyaluronate and D-panthenol, TREHAPAN^® eye drops protect, hydrate, repair and re-generate the ocular surface for all dry eye patients.^1-3

TREHAPAN^® is for those who need intense hydration, for those who are unable to adequately manage their symptoms with other drops, for those with corneal damage due to persistent Dry Eye or surgery, for those who suffer with environmental Dry Eye, for those who regularly wear contact lenses and need longer-lasting comfort, or for those who require a softer bottle due to dexterity issues.^1,3,5 TREHAPAN^® eye drops are preservative and phosphate free, contact lens friendly and come in a 10 ml soft and easy-to-use bottle.¹ It is recommended to apply 1 drop into the conjunctival sac of the eye 3 times a day.¹

Download instructions for use

Watch TREHAPAN®’s Innovative Mode of Action Video

1. TREHAPAN^® Instruction for Use (IFU).
2. Proksch E, et al. Topical use of dexpanthenol: a 70th anniversary Article. JOURNAL OF DERMATOLOGICAL TREATMENT 2017;28(8):766–773.
3. Szumny D and Misiuk-Hojlo M. Dexpanthenol in the treatment of corneal disorders and injuries. Opthatherapy. Vol.9 / Nr3 (35)/2022 (195-199).
4. Luyck J, et al. Trehalose: an intriguing disaccharide with potential for medical application in ophthalmology. Clin ophtalmol 2011;5:577–581.
5. Guarise C, et al. The role of high molecular weight hyaluronic acid in mucoadhesion on an ocular surface model. J Mechanical Behavior of biomed Materials 2023;143:105908.

VisuEVO^®

The first multitasking eye drop for long lasting relief of evaporative dry eye

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VisuEVO^® is an innovative preservative free formulation containing omega-3 essential fatty acids, Vitamin A, Vitamin D and ultra-filtered phospholipids.¹

VisuEVO^® key features
• The first multitasking eye drop¹
• Reduces excessive evaporation of the tear film¹
• Protects from a wide range of dry eye conditions¹
• Improves inflammatory markers²
• Restores the tear quality¹
• Provides immediate long-lasting relief from dry eye¹
• Contact lens friendly¹
• Preservative free¹

Due to the presence of phospholipids, omega-3 and Vitamin D, VisuEVO^®restores the tear quality and reduces excessive evaporation of the tear film, which is caused by inflammatory conditions on the surface of the eye.¹

Vitamin A and phospholipids are natural constituents of the tear film, and their antioxidant action prevents damage caused by reactive oxygen species and facilitates homeostasis and the retention of the tear film.1 Vitamin A and phospholipids control the evaporation of the tear film.¹

VisuEVO^® is recommended for all patients suffering from evaporative dry eye, as pre-treatment for eye surgery, for forms of dry eye caused by a reduced secretion of lipids from the Meibomian glands and for cases of dry eye caused by a mucin deficiency.¹

VisuEVO^® is contact lens friendly.¹

VisuEVO^® comes in a 10ml preservative free Novelia System® bottle.¹

Thanks to the presence of phospholipids, omega-3 and Vitamin D, VisuEVO® reduces excessive evaporation of the tear film, caused by inflammatory conditions on the surface of the eye.¹

Omega-3, Vitamin D and phospholipids improve the osmolarity of the tear film, protecting it from inflammatory condition caused by excessive evaporation.¹

Vitamin A and phospholipids facilitate homeostasis and the retention of the tear film, as well as the control of its evaporation.¹

Watch VisuEVO^® Mode of Action Video

Buy now Download instructions for use Further information Safety is of paramount importance to the pharmaceutical industry. VISUfarma makes every effort to provide helpful, accurate information which is compliant with industry regulations.

1. Package leaflet: Information for the user VisuEVO^®.
2. Quisisana C, Rosetti L, Caretti A, Dei Cas M, Fogagnolo P. The Efficacy of a New lubricating Eyedrop in a Lipid
Vehicle for the Treatment of Dry Eye Disease. J Clin Exp Ophthalmol. Vol. 11. Iss.6.

VisuXL^® Gel

The advanced lubricating dry eye treatment providing 12 hour protection* with just 1 drop for day and night use
*in an animal model

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VisuXL^® Gel is the first smart gel,^2-5 transforming from a drop in the bottle to a gel in the eye. It is based on a unique combination of ingredients including Coenzyme Q10 (CoQ10), Cross-linked sodium carboxymethylcellulose (Cross-linked CMC) and Poloxamer 407.¹

VisuXL^® Gel is recommended for dry eye patients who want long-lasting comfort from dry eye sensations with less drops per day. VisuXL^® provides 12 hour protection* with just 1 drop, and can be used for both day and night relief.^1,6

VisuXL^® Gel is a preservative free eye drop which is contact lens friendly and is available in a 5ml or 10ml comfort grip bottle which lasts 2 months with the recommended usage, with an opened bottle lasting 6 months.¹

VisuXL^® Gel key features
• Forms a protective cushion on the ocular surface¹
• Provides the benefits of a gel in the convenience of a drop
• Repairs and prevents damage to the ocular surface^6*,7*,8
• Non-irritant and non-sensitising^10*
• Day and night use¹
• 12 hour protection with just 1 drop^1,6*
• Each 10ml bottle lasts 2 months¹
• Preservative-free¹
• Contact lens friendly¹
• Comfort grip bottle with thumb lever
• Can be used for 180 days after opening¹
• Available in a 5ml and 10ml comfort grip bottle

First smart gel^2-5

It transforms from liquid into a gel when it comes in contact with the ocular surface, thanks to Poloxamer 407, a thermo-gelling agent.^2-4 With VisuXL^® Gel patients would experience all the benefits of traditional gels but in the convenience of a drop.

Day and night use¹

Carboxymethyl Cellulose (CMC) has been cross-linked to form a hydrogel which increases lubrication and prolongs residence time.⁵ VisuXL^® Gel provides day and night protection with just 2 drops.^1,6*

Long-lasting protection^1,6*

The Coenzyme Q10 (CoQ10) helps to repair damaged cells promoting a healthy ocular surface.^6*,7*,8,9* The cross-linked CMC captures the CoQ10 molecules and the increased residence time provides lasting protection.^1,6*

*Based on animal model

Watch VisuXL® Gel’s Innovative Mode of Action Video

1. VisuXL® Gel Instructions for Use (IFU).
2. Ibrahim SS. J Pharm Sci 2019; 108(6): 1923-1933.
3. Almeida H, et al. Expert Opin Drug Deliv 2013; 10(9): 1223-1237.
4. Dumortier G, et al. Pharm Res 2006; 23(12): 2709-2728
5. Kono H. Carbohydrate Polymers 2014; 106: 84-93
6. Brancato R, et al. J Refractive Surgery 2002; 18: 135-139
7. Mencucci R, et al. Invest Ophthalmol Vis Sci 2014; 55: 7266-7271.
8. Gumus K. Eye Contact Lens 2017; 43(2): 73-80.
9. Brancato R, et al. Eur J Ophthalmol 2000; 10(1): 32-38.
10. VISUfarma Data on File.

VisuXL^®

More effective than HA alone, lasting lubrication,* and with the additional benefit of ocular surface healing for damage caused by persistent dry eye disease or surgery
*in an animal model

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VisuXL^® is a lubricating and antioxidant solution without preservatives, composed of Coenzyme Q10, Vitamin E TPGS and cross-linked hyaluronic acid. The cross-linked hyaluronic acid is a more stable and effective form of hyaluronic acid than the linear form of HA and gives VisuXL^® better viscoelastic, mucomimetic and moisturising properties and is more effective over time.^1,2

VisuXL^® key features
• Repairs and prevents damage on the ocular surface^1,2,3,4
• Greater relief compared to HA drops²
• 2 drops per day^1,4
• 12 hourly dosing^1,4
• Each 10ml bottle lasts 2 months¹
• Preservative-free^1,4
• Contact lens friendly^1,4
• Can be used for 180 days after opening¹
• Available in a 5ml and 10ml bottle, as well as unit dose vials

VisuXL^® is recommended for dry eye patients that require lasting lubrication^1,4,5* to relieve dry eye sensations, with the additional benefit of ocular surface healing for damage caused by persistent dry eye disease or surgery^1,2,3,4 as VisuXL^® is more effective than HA alone.²

Relieve

VisuXL^® patients feel better compared to treatment with HA alone.²

Restore

VisuXL^® supports the restoration of a healthy ocular surface.²

2 Drops

Watch VisuXL^® Mode of Action Video

1. VisuXL® Instructions for Use.
2. Postorino E, et al. Efficacy of eye drops containing cross-linked hyaluronic acid and coenzyme Q10 treating patients with mild to moderate dry eye. Eur J Ophthalmol 2018;28(1): 25-31.
3. Fogagnolo P, et al. The Effects of Topical Coenzyme Q 10 and Vitamin E D – α -Tocopheryl Polyethylene Glycol 1000 Succinate after Cataract Surgery: A Clinical and in vivo Confocal Study. Ophthalmologica 2013; 229: 26-31.
4. VisuXL® UD Instructions for Use, March 2021, VISUfarma.
5. Muzzi M, Mencucci R. Poster presented at the Association for Ocular Pharmacology and Therapeutics (AOPT) 13th Scientific Meeting, February 16-19, 2017. Florence, Italy.

*in an animal model

The Xailin^® Eye Health Range

A range for your dry eye needs that's preservative & phosphate free and contact lens friendly.^1-3

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CROSS OUT DRY EYE with VISUfarma’s Xailin® range, a customised solution for your individual needs.
The 3 product range combines lubricating and moisturising eye drops with varying concentrations of sodium hyaluronate (HA) for varying patients needs.

The Xailin® range is preservative & phosphate free and is suitable to use with all types of contact lenses.^1-3

The range includes:

Xailin® TEARS: 0.1% HA
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Xailin® PLUS: 0.2% HA
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Xailin® INTENSE: 0.3% HA
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1. Xailin® Tears Instructions for Use (IFU)
2. Xailin® Plus Instructions for Use (IFU)
3. Xailin® Intense Instructions for Use (IFU)

Xailin^®

A comprehensive range of ocular lubricants to relieve and refresh dry eyes

Our comprehensive range of Xailin^® ocular lubricants relieve and refresh dry eyes and suits all of the dry eye patients’ needs.^1-6Using widely prescribed, trusted ingredients all products in the range are presented in easy-to-use devices.

The range includes:

Xailin^® HA

(Sodium Hyaluronate 0.2%) multi-dose 10ml bottle.¹

Xailin^® HA is a preserved sterile hypotonic multi-dose lubricating eye drop containing 0.2% sodium hyaluronate for the lasting relief of dry eye symptoms including irritated and tired eyes caused by external factors such as prolonged exposure to video screens, air conditioning, dust, pollution, smoke, etc.¹

Xailin^® HA key features
• Contains Sodium Hyaluronate, a naturally occurring ingredient used in eye drops.
• It maintains and restores the physiological conditions of the eye surface providing long-lasting relief from dry eye sensations including irritated and tired eyes.
• Contact lens friendly.
• Presented in a 10ml multi-dose bottle.

Download instructions for use
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Xailin^® Hydrate
(Hypromellose 0.3%) multi-dose 10ml bottle.²

Xailin^® Hydrate provides soothing, moisturising and lubricating properties for long-lasting relief from ocular discomfort and irritation associated with dry eyes, tiredness and environmental factors such as wind, salt water, smoke or computer work. Ideal for the treatment of mild, occasional or temporary forms of dry eye.²

Xailin^® Hydrate contains a gentle preservative which has significantly less adverse reactions compared with traditional preservatives such as benzalkonium chloride.^2*

Xailin^® Hydrate key features²
• Contact lens friendly.
• Contains Hypromellose, a trusted lubricant widely prescribed for treating dry eye.
• Provides long-lasting relief from dry eye sensations.
• Presented in a traditional, easy to use 10ml multi-dose bottle.

* Xailin^® Hydrate previously contained perborate, and now contains stabilised oxychloro complex (SOC).

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Xailin^® Fresh
(Carmellose 0.5%) unit dose vials 30 x 0.4ml.³

Xailin^® Fresh is a preservative-free long-lasting lubricant that soothes and relieves dry eye sensations such as red, sore, dry and gritty eyes. These contact lens friendly eye drops contain carmellose and are presented in convenient 30 x 0.4ml single use preservative-free vials. Xailin® Fresh can also be used as a contact lens hydrating solution.³

Xailin^® Fresh key features³
• Preservative-free.
• Contact lens friendly.
• Can also be used as a contact lens hydrating solution.
• Provides long-lasting lubrication while hydrating and nourishing the eye’s surface.
• Contains carmellose sodium, a trusted lubricant widely prescribed for treating dry eye.
• Is presented in a single-use 0.4ml unit dose vial.

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Xailin^® Gel
(Carbomer 0.2%) multi-dose 10g tube.^4*

Xailin^® Gel is a viscous and hypotonic Carbomer Gel lubricant for the long-lasting relief of dry eye sensations. Carbomer Gel has excellent mucoadhesive properties which evenly coats and lubricates the corneal and conjunctival surfaces, alleviating symptoms of dryness, discomfort, grittiness and minor irritation caused by dry eye.⁴

Contact lenses should be removed prior to application of Xailin^® Gel and reinserted after 30 minutes.⁴

Xailin^® Gel key features⁴
• Provides lasting relief with its lubricating properties to alleviate the symptoms of dryness, discomfort, grittiness and minor irritation caused by dry eye
• Has excellent mucoadhesive properties which evenly coats and lubricates the surface of the eye.
• Can be used throughout the day (usual dosage one drop to be applied 3-4 times per day as needed) for greater dry eye relief.
• Presented in a 10 g multi-dose tube

* Xailin^® Gel previously contained perborate, and now contains cetrimide.

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Xailin^® Night

(Soft White Paraffin, White Mineral Oil, Lanolin Alcohols) multi-dose 5g tube.⁵

Xailin^® Night is a preservative-free lubricating ointment providing soothing relief from night-time dry eye sensations, acting as a barrier against moisture loss.⁵

Xailin^® Night key features⁵
• Preservative-free.
• Provides a lubricating and moisture-retaining film on the surface of the eye, acting as a barrier against moisture loss.
• Long-lasting night-time protection.
• Easy to use plastic tube for controlled application.
• Trusted ingredients – Xailin^® Night is a widely used White Soft Paraffin based ointment.
• Presented in a 5g multi-dose tube.

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Xailin^® Wash
(Sodium chloride – 0.3%) Preservative-free single dose eye wash solution 20 x 5ml.⁶

Xailin^® Wash is a sterile, preservative-free eyewash.⁶

Xailin^® Wash key features⁶:
• Preservative-free.
• Can be used to treat eyelid irritation due to infection, allergy or foreign body.
• Can be used for daily post-surgical eye cleansing.
• Can help hydrate your eyes.
• Presented in sterile, preservative-free 5ml unit dose vials.
Download instructions for use
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Further information Safety is of paramount importance to the pharmaceutical industry. VISUfarma makes every effort to provide helpful, accurate information which is compliant with industry regulations.

1. Xailin® HA Instructions for Use, May 2022, VISUfarma.
2. Xailin® Hydrate Instructions for Use, May 2023, VISUfarma.
3. Xailin® Fresh Instructions for Use, April 2023, VISUfarma
4. Xailin® Gel Instructions for Use, May 2023, VISUfarma.
5. Xailin® Night Instructions for Use, May 2023, VISUfarma.
6. Xailin® Wash Instructions for Use, November 2022, VISUfarma.
7. VISUfarma Data on File, May 2020.

Back to Eye Health

Ocular Lubricants

Dry Eye Syndrome

Dry Eye Syndrome

TREHAPAN®

VisuEVO®

VisuXL® Gel

VisuXL®

The Xailin® Eye Health Range

Xailin®

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Ocular
Lubricants

Dry Eye
Syndrome

TREHAPAN^®

VisuEVO^®

VisuXL^® Gel

VisuXL^®

The Xailin^® Eye Health Range

Xailin^®